A recent publication by a research group around D. Payen sheds light on genetic factors associated with increased mortality risk in septic shock. Besides, environmental factors and comorbidities, genetic predisposition plays a key role in regulation of the host response to infection. By genome-wide association studies, several genes associated with death in patients with septic shock could be identified; Variations in key genes are thought to perturb relevant pathways and thus increase the risk of death in sepsis patients. This is exemplified by a number of significant single nucleotide polymorphisms (SNPs) that were identified within the CISH gene, which is involved in cytokine regulation.
Full article:
Rosier F, Brisebarre A, Dupuis C, Baaklini S, Puthier D, Brun C, Pradel LC, Rihet P, Payen D (2021) Genetic Predisposition to the Mortality in Septic Shock Patients: From GWAS to the Identification of a Regulatory Variant Modulating the Activity of a CISH Enhancer. International Journal of Molecular Sciences 22: 5852
