In a recent article in Intensive Care Med, EGIS member Matthijs Kox and his team applied machine learning approaches on routine clinical parameters of thousands of critically ill patients affected with COVID-19. Three distinct phenotypes were derived (COVIDICU1-3), each displaying diverse immunological signatures. Only in patients with the hyperinflammatory COVIDICU3 phenotype, late and short-term corticosteroid therapy was not associated with worse survival.
Bruse N et al. Clinical phenotyping uncovers heterogeneous associations between corticosteroid treatment and survival in critically ill COVID-19 patients. Intensive Care Med. 2024;50(11):1884-96. DOI: 10.1007/s00134-024-07593-3
