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Seroprevalence of SARS-CoV-2 antibodies in a quarantined community after a COVID-19 outbreak
Continue reading →: Seroprevalence of SARS-CoV-2 antibodies in a quarantined community after a COVID-19 outbreakThe small community of Neustadt-am-Rennsteig near Jena experienced an outbreak of SARS-CoV-2 in March 2020. Weis et al. conducted a population-based cohort study with 71% of the village population on COVID seroprevalence six weeks after the outbreak, including mandatory PCR testing for all residents. About half of the subjects with…
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Sepsis therapies – learning from decades of translational research
Continue reading →: Sepsis therapies – learning from decades of translational researchThree decades of sepsis research resulted in major progress in understanding the underlying pathophysiology. However, these successes have been thwarted by failing translation to sepsis therapies. J-M. Cavaillon and colleagues recently provided a comprehensive review on current knowledge, lessons learned from failing trials and novel approaches. Cavaillon J-M, Singer M, Skirecki…
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Homeopathy for sepsis treatment
Continue reading →: Homeopathy for sepsis treatmentBavarian regional parlament has most recently voted for a large, long controversially debated homeopathy study for sepsis treatment, see link below (in German!). Seems like clinical sepsis research will not stagnate any longer…. and rather move backwards. I. Rubio ZEIT ONLINE: Bayerischer Landtag stimmt für umstrittene Homöopathie-Studie (7. Nov 2019)
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Current gaps in sepsis immunology: new opportunities for translational research
Continue reading →: Current gaps in sepsis immunology: new opportunities for translational researchIncreasing evidence supports a central role of the immune system in sepsis, but the current view of how sepsis affects immunity, and vice versa, is still rudimentary. The European Group on Immunology of Sepsis has identified major gaps that should be addressed with high priority, such as understanding how immunological…
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MOOC Innate Immunity – A new free online course of the Institut Pasteur
Continue reading →: MOOC Innate Immunity – A new free online course of the Institut PasteurThis MOOC is aimed to offer the most up-dated information on the cellular and molecular players of innate immunity, and on the mechanisms that lead to the elimination of the pathogens, of either bacterial, viral, fungal or parasitic origin. Accordingly, strategies of the pathogens against the innate immune system are…
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Validation of a Host Response Assay for Discriminating Sepsis from SIRS
Continue reading →: Validation of a Host Response Assay for Discriminating Sepsis from SIRSThe article reports on the diagnostic performance of a molecular test (SeptiCyte LAB) to distinguish between sepsis and systemic inflammation of noninfectious etiology in critically ill adults. Miller RR, 3rd, Lopansri BK, Burke JP, Levy M, Opal S, Rothman RE, D’Alessio FR, Sidhaye VK, Aggarwal NR, Balk R, Greenberg JA,…
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Call for participation – Frontiers in Immunology
Continue reading →: Call for participation – Frontiers in ImmunologyThe long-term consequences of sepsis on the immune system are currently only scarcely understood. Aiming to promote research on this critical gap, EGIS member Dr. Florian Uhle, together with the journal “Frontiers in Immunology” initiated the research topic “Long-term Consequences of Sepsis and Severe Trauma on Innate and Adaptive Immunity”.…
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ImmuneRegulation: a web-based tool for identifying human immune regulatory elements
Continue reading →: ImmuneRegulation: a web-based tool for identifying human immune regulatory elementsThis paper by Kalayci et al. describes an interesting, new, and freely accessible web-based tool for the identification of human genes/proteins involved in disease-associated immune regulation. This might be useful also to research on the immunology of sepsis. Kalayci S, Selvan ME, Ramos I, Cotsapas C, Harris E, Kim E-Y,…
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Sepsis Update 2019
Continue reading →: Sepsis Update 2019The 9th international congress “Sepsis & Multiorgan Dysfunction” will take place from 11 – 13 September 2019 in Weimar. As a part of the programme, the EGIS will hold a workshop on 11 September 2019. We are looking forward to seeing you there!
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Characterizing the immunophenotypes of lymphopenic community-acquired pneumonia
Continue reading →: Characterizing the immunophenotypes of lymphopenic community-acquired pneumoniaCommunity-acquired pneumonia (CAP) is the leading cause of sepsis. Whereas the host response has been analyzed regarding innate immunity and inflammatory response, adaptive immunity remained largely unexplored. Méndez et al. aimed to contribute to detailed immunoprofiling in CAP by evaluating the host’s adaptive immunity.
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